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1

A novel small-molecule inhibitor of IL-6 signalling

Giovanna Zinzalla, Mohammad R. Haque, B. Piku Basu, John Anderson, Samantha L. Kaye, Shozeb Haider, Fyeza Hasan, Dyeison Antonow, Samantha Essex, Khondaker M. Rahman, Jonathan Palmer, Daniel Morgenste

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 431 KB

english, 2010

2

Understanding and Exploiting Protein–Protein Interactions as Drug Targets || Understanding and exploiting protein–protein interactions as drug targets

Zinzalla, Giovanna

Year:

2013

Language:

english

File:

PDF, 596 KB

english, 2013

3

Chemical Variation of Natural-Product-Like Scaffolds: Design, Synthesis, and Biological Activity of Fused Bicyclic Acetal Derivatives

Lech-Gustav Milroy, Giovanna Zinzalla, Giuseppe Prencipe, Patrick Michel, Steven V. Ley, Mekala Gunaratnam, Monica Beltran, Stephen Neidle

Journal:

Angewandte Chemie

Year:

2007

Language:

english

File:

PDF, 166 KB

english, 2007

4

Chemical Variation of Natural-Product-Like Scaffolds: Design, Synthesis, and Biological Activity of Fused Bicyclic Acetal Derivatives

Lech-Gustav Milroy, Giovanna Zinzalla, Giuseppe Prencipe, Patrick Michel, Steven V. Ley, Mekala Gunaratnam, Monica Beltran, Stephen Neidle

Journal:

Angewandte Chemie International Edition

Year:

2007

Language:

english

File:

PDF, 167 KB

english, 2007

5

ChemInform Abstract: Stereoselective Hetero Diels—Alder Reactions of Chiral Tricarbonyl (η6-Benzaldehyde)chromium Complexes.

Clara Baldoli, Stefano Maiorana, Emanuela Licandro, Giovanna Zinzalla, Maurizio Lanfranchi, Antonio Tiripicchio

Journal:

Year:

2002

File:

PDF, 42 KB

2002

6

ChemInform Abstract: Facile Oxidation of Electron-Poor Benzo[b]thiophenes to the Corresponding Sulfones with an Aqueous Solution of H2O2 and P2O5.

Dyeison Antonow, Teresa Marrafa, Irfaan Dawood, Tauheed Ahmed, Mohammad R. Haque, David E. Thurston, Giovanni Zinzalla

Journal:

Year:

2010

File:

PDF, 49 KB

2010

7

ChemInform Abstract: One-Pot Synthesis of Fused-Tetracyclic Scaffolds Employing a Lewis Acid Promoted Domino Reaction of Naphthoquinones.

Yassine Bendiabdellah, Isabel Villanueva-Margalef, Antonio Misale, Kazi S. Nahar, Mohammad R. Haque, David E. Thurston, Giovanna Zinzalla

Journal:

Year:

2011

File:

PDF, 38 KB

2011

8

Natural-Product-Like Spiroketals and Fused Bicyclic Acetals as Potential Therapeutic Agents for B-Cell Chronic Lymphocytic Leukaemia

Lech-Gustav Milroy, Giovanna Zinzalla, François Loiseau, Zizheng Qian, Giuseppe Prencipe, Chris Pepper, Chris Fegan, Steven V. Ley

Journal:

Year:

2008

Language:

english

File:

PDF, 535 KB

english, 2008

9

Mathematical modeling of DNA replication

Bruemmer, Anneke, Salazar, Carlos, Zinzalla, Vittoria, Alberghina, Lilia, Hoefer, Thomas

Journal:

Journal of Biotechnology

Year:

2010

Language:

english

File:

PDF, 61 KB

english, 2010

10

Stereoselective hetero Diels–Alder reactions of chiral tricarbonyl (η6-benzaldehyde)chromium complexes

Clara Baldoli, Stefano Maiorana, Emanuela Licandro, Giovanna Zinzalla, Maurizio Lanfranchi, Antonio Tiripicchio

Journal:

Tetrahedron: Asymmetry

Year:

2001

Language:

english

File:

PDF, 249 KB

english, 2001

11

A new ferrocene conjugate of a tyrosine PNA monomer: synthesis and electrochemical properties

Clara Baldoli, Luigi Falciola, Emanuela Licandro, Stefano Maiorana, Patrizia Mussini, Prasanna Ramani, Clara Rigamonti, Giovanna Zinzalla

Journal:

Journal of Organometallic Chemistry

Year:

2004

Language:

english

File:

PDF, 378 KB

english, 2004

12

Erratum to “A new ferrocene conjugate of a tyrosine PNA monomer: synthesis and electrochemical properties” [J. Organomet. Chem. 689 (25) (2004) 4791]

Clara Baldoli, Luigi Falciola, Emanuela Licandro, Stefano Maiorana, Patrizia Mussini, Prasanna Ramani, Clara Rigamonti, Giovanna Zinzalla

Journal:

Journal of Organometallic Chemistry

Year:

2006

Language:

english

File:

PDF, 50 KB

english, 2006

13

Rapamycin-mediated G1 arrest involves regulation of the Cdk inhibitor Sic1 in Saccharomyces cerevisiae

Vittoria Zinzalla, Michele Graziola, Andrea Mastriani, Marco Vanoni, Lilia Alberghina

Journal:

Molecular Microbiology

Year:

2007

Language:

english

File:

PDF, 537 KB

english, 2007

14

Signal transduction: Linking nutrients to growth

Zinzalla, Vittoria, Hall, Michael N.

Journal:

Year:

2008

Language:

english

File:

PDF, 391 KB

english, 2008

15

Molecular Dynamics Studies of the STAT3 Homodimer:DNA Complex: Relationships between STAT3 Mutations and Protein–DNA Recognition

Husby, Jarmila, Todd, Alan K., Haider, Shozeb M., Zinzalla, Giovanna, Thurston, David E., Neidle, Stephen

Journal:

Journal of Chemical Information and Modeling

Year:

2012

Language:

english

File:

PDF, 941 KB

english, 2012

16

Sic1 is phosphorylated by CK2 on Ser201 in budding yeast cells

Paola Coccetti, Vittoria Zinzalla, Gabriella Tedeschi, Gian Luigi Russo, Sonia Fantinato, Oriano Marin, Lorenzo A. Pinna, Marco Vanoni, Lilia Alberghina

Journal:

Biochemical and Biophysical Research Communications

Year:

2006

Language:

english

File:

PDF, 242 KB

english, 2006

17

In CK2 inactivated cells the cyclin dependent kinase inhibitor Sic1 is involved in cell-cycle arrest before the onset of S phase

Farida Tripodi, Vittoria Zinzalla, Marco Vanoni, Lilia Alberghina, Paola Coccetti

Journal:

Biochemical and Biophysical Research Communications

Year:

2007

Language:

english

File:

PDF, 261 KB

english, 2007

18

Activation of mTORC2 by Association with the Ribosome

Vittoria Zinzalla, Daniele Stracka, Wolfgang Oppliger, Michael N. Hall

Journal:

Year:

2011

Language:

english

File:

PDF, 1.21 MB

english, 2011

19

Small-Molecule Inhibition of c-MYC:MAX Leucine Zipper Formation Is Revealed by Ion Mobility Mass Spectrometry

Harvey, Sophie R., Porrini, Massimiliano, Stachl, Christiane, MacMillan, Derek, Zinzalla, Giovanna, Barran, Perdita E.

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 478 KB

english, 2012

20

Facile nucleophilic substitution at the C3a tertiary carbon of the 3a-bromohexahydropyrrolo[2,3-b]indole scaffold

Villanueva-Margalef, Isabel, Thurston, David E., Zinzalla, Giovanna

Journal:

Organic & Biomolecular Chemistry

Year:

2010

Language:

english

File:

PDF, 396 KB

english, 2010

21

113 Novel small-molecule inhibitors of Interleukin-6 (IL-6) signalling

M. Haque, G. Zinzalla, B.P. Basu, J. Anderson, S. Haider, F. Hasan, D. Antonow, D. Morgenstern, S. Neidle, D.E. Thurston

Journal:

European Journal of Cancer Supplements

Year:

2010

Language:

english

File:

PDF, 55 KB

english, 2010

22

Synthesis of Chiral Chromium Tricarbonyl Labeled Thymine PNA Monomers via the Ugi Reaction

Baldoli, Clara, Maiorana, Stefano, Licandro, Emanuela, Zinzalla, Giovanna, Perdicchia, Dario

Journal:

Organic Letters

Year:

2002

Language:

english

File:

PDF, 67 KB

english, 2002

23

Targeting protein–protein interactions for therapeutic intervention: a challenge for the future

Zinzalla, Giovanna, Thurston, David E

Journal:

Future Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 2.17 MB

english, 2009

24

One-Pot Synthesis of Fused-Tetracyclic Scaffolds Employing a Lewis Acid Promoted Domino Reaction of Naphthoquinones

Bendiabdellah, Yassine, Villanueva-Margalef, Isabel, Misale, Antonio, Nahar, Kazi, Haque, Mohammad, Thurston, [nl]David, Zinzalla, Giovanna

Journal:

Year:

2011

Language:

english

File:

PDF, 234 KB

english, 2011

25

Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography

Nkansah, Edwin, Shah, Rahi, Collie, Gavin W., Parkinson, Gary N., Palmer, Jonathan, Rahman, Khondaker M., Bui, Tam T., Drake, Alex F., Husby, Jarmila, Neidle, Stephen, Zinzalla, Giovanna, Thurston, Da

Journal:

Year:

2013

Language:

english

File:

PDF, 1.04 MB

english, 2013

26

LIVERPOOL MEDICAL INSTITUTION.

Heidelberger, Sibylle, Zinzalla, Giovanna, Antonow, Dyeison, Essex, Samantha, Piku Basu, B., Palmer, Jonathan, Husby, Jarmila, Jackson, Paul J.M., Rahman, Khondaker M., Wilderspin, Andrew F., Zloh, Mi

Journal:

Year:

1898

Language:

english

File:

PDF, 444 KB

english, 1898

27

Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry

Heidelberger, Sibylle, Zinzalla, Giovanna, Antonow, Dyeison, Essex, Samantha, Piku Basu, B., Palmer, Jonathan, Husby, Jarmila, Jackson, Paul J.M., Rahman, Khondaker M., Wilderspin, Andrew F., Zloh, Mi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 876 KB

english, 2013

28

Tetracycline analogues with a selective inhibitory effect on HIF-1α

Bendiabdellah, Y., Rahman, K. M., Uranchimeg, B., Nahar, K. S., Antonow, D., Shoemaker, R. H., Melillo, G., Zinzalla, G., Thurston, D. E.

Journal:

Year:

2014

Language:

english

File:

PDF, 338 KB

english, 2014

29

Polymer-Supported Haloarene Chromium Dicarbonyl Isonitrile Complexes: A Study of Their Synthesis and Reactivity

Baldoli, Clara, Maiorana, Stefano, Licandro, Emanuela, Casiraghi, Laura, Zinzalla, Giovanna, Seneci, Pierfausto, De Magistris, Elisabetta, Paio, Alfredo, Marchioro, Carla

Journal:

Journal of Combinatorial Chemistry

Year:

2003

Language:

english

File:

PDF, 88 KB

english, 2003

30

Facile oxidation of electron-poor benzo[b]thiophenes to the corresponding sulfones with an aqueous solution of H2O2 and P2O5

Antonow, Dyeison, Marrafa, Teresa, Dawood, Irfaan, Ahmed, Tauheed, Haque, Mohammad R., Thurston, David E., Zinzalla, Giovanna

Journal:

Chemical Communications

Year:

2010

Language:

english

File:

PDF, 539 KB

english, 2010

31

Chemical variation of natural product-like scaffolds: design and synthesis of spiroketal derivatives

Zinzalla, Giovanna, Milroy, Lech-Gustav, Ley, Steven V.

Journal:

Organic & Biomolecular Chemistry

Year:

2006

Language:

english

File:

PDF, 853 KB

english, 2006

32

[The Enzymes] Volume 27 || TOR Complexes

Zinzalla, Vittoria

Year:

2010

Language:

english

File:

PDF, 1.04 MB

english, 2010

33

Mathematical Modelling of DNA Replication Reveals a Trade-off between Coherence of Origin Activation and Robustness against Rereplication

Brümmer, Anneke, Salazar, Carlos, Zinzalla, Vittoria, Alberghina, Lilia, Höfer, Thomas, Alter, Orly

Journal:

PLoS Computational Biology

Year:

2010

Language:

english

File:

PDF, 623 KB

english, 2010

34

Targeting protein–protein interactions (PPIs) of transcription factors: Challenges of intrinsically disordered proteins (IDPs) and regions (IDRs)

Sammak, Susan, Zinzalla, Giovanna

Journal:

Progress in Biophysics and Molecular Biology

Year:

2015

Language:

english

File:

PDF, 1.40 MB

english, 2015

35

A Thymine-PNA Monomer as New Isocyanide Component in the Ugi Reaction: A Direct Entry to PNA Dimers

Baldoli, Clara, Giannini, Clelia, Licandro, Emanuela, Maiorana, Stefano, Zinzalla, Giovanna

Journal:

Year:

2004

Language:

english

File:

PDF, 75 KB

english, 2004

36

Paving the way to targeting HECT ubiquitin ligases

Zinzalla, Giovanna

Journal:

Future Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.10 MB

english, 2015

37

The SWI/SNF Subunit INI1 Contains an N-Terminal Winged Helix DNA Binding Domain that Is a Target for Mutations in Schwannomatosis

Allen, Mark D., Freund, Stefan M.V., Zinzalla, Giovanna, Bycroft, Mark

Journal:

Year:

2015

Language:

english

File:

PDF, 1.98 MB

english, 2015

38

Subcellular Localization of the Cyclin Dependent Kinase Inhibitor Sic1 is Modulated by the Carbon Source in Budding Yeast

Rossi, Riccardo L., Zinzalla, Vittoria, Mastriani, Andrea, Vanoni, Marco, Alberghina, Lilia

Journal:

Year:

2005

Language:

english

File:

PDF, 939 KB

english, 2005

39

A New Way Forward in Cancer Drug Discovery: Inhibiting the SWI/SNF Chromatin Remodelling Complex

Zinzalla, Giovanna

Journal:

Year:

2016

Language:

english

File:

PDF, 667 KB

english, 2016

40

Glucose modulation of cell size in yeast: Figure 1

Vanoni, M., Rossi, R.L., Querin, L., Zinzalla, V., Alberghina, L.

Journal:

Biochemical Society Transactions

Year:

2005

Language:

english

File:

PDF, 126 KB

english, 2005

41

Targeting MYC: is it getting any easier?

Zinzalla, Giovanna

Journal:

Future Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.10 MB

english, 2016

42

Understanding and Exploiting Protein–Protein Interactions as Drug Targets || Biochemical assays and biophysical tools for inhibitor identification and validation

Zinzalla, Giovanna

Year:

2013

Language:

english

File:

PDF, 1.98 MB

english, 2013

43

A selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferation

Castell, Alina, Yan, Qinzi, Fawkner, Karin, Hydbring, Per, Zhang, Fan, Verschut, Vasiliki, Franco, Marcela, Zakaria, Siti Mariam, Bazzar, Wesam, Goodwin, Jacob, Zinzalla, Giovanna, Larsson, Lars-Gunna

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 10.80 MB

english, 2018

44

The structure of INI1/hSNF5 RPT1 and its interactions with the c-MYC:MAX heterodimer provide insights into the interplay between MYC and the SWI/SNF chromatin remodeling complex

Sammak, Susan, Allen, Mark D., Hamdani, Najoua, Bycroft, Mark, Zinzalla, Giovanna

Journal:

Year:

2018

Language:

english

File:

PDF, 1.47 MB

english, 2018

45

Crystal structures and NMR studies of the apo form of the c-MYC:MAX bHLHZip complex reveal a helical basic region in the absence of DNA.

Sammak, Susan, Hamdani, Najoua, Gorrec, Fabrice, Allen, Mark, Freund, Stefan M.V., Bycroft, Mark, Zinzalla, Giovanna

Journal:

Year:

2019

Language:

english

File:

PDF, 1.12 MB

english, 2019

46

Structure of the BRK domain of the SWI/SNF chromatin remodelling complex subunit BRG1 reveals a potential role in protein–protein interactions

Allen, Mark D., Bycroft, Mark, Zinzalla, Giovanna

Journal:

Protein Science

Year:

2020

File:

PDF, 1.91 MB

2020

47

Understanding and Exploiting ProteinâProtein Interactions as Drug Targets || Computational approaches for the design of proteinâprotein interaction inhibitors

Zinzalla, Giovanna

Year:

2013

File:

PDF, 2.08 MB

2013